The next-generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner
AUTHORS
Erkes, et al
Programs
OPN-51107
https://doi.org/10.1111/pcmr.12788
Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma
AUTHORS
Ambrosini, et al
Programs
OPN-51107
https://doi.org/10.1158/0008-5472.CAN-18-3177
Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma
AUTHORS
Chua, et al
Programs
OPN-51107
https://doi.org/10.15252/emmm.201809081
BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade
AUTHORS
Nikbakht, et al
Programs
OPN-51107
https://doi.org/10.1016/j.jid.2018.12.024
ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition
AUTHORS
Roberts, et al
Programs
OPN-7486
https://doi.org/10.1182/blood-2018-05-849554
Blocking colony stimulating factor 1 receptor (CSF-1R) and tropomyosin receptor kinase A (TrkA) improves the antitumor efficacy of immune checkpoint blockade
AUTHORS
Duffy, et al
Programs
OPN-7486
https://www.jimmunol.org/content/200/1_Supplement/122.15/tab-article-info
Phase 1b/2a Study of PLX51107, a Small Molecule BET Inhibitor, in Subjects with Advanced Hematological Malignancies and Solid Tumors
AUTHORS
Patnaik, et al
Programs
OPN-2853
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BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
AUTHORS
Ozer , et al
Programs
OPN-51107
https://doi.org/10.1158/2159-8290.CD-17-0902
b2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer
AUTHORS
Renz, et al
Programs
OPN-7486
https://doi.org/10.1016/j.ccell.2017.11.007
Resistance to BET inhibitors involves the Wnt/β-catenin Pathway in Uveal Melanoma
AUTHORS
Ambrosini, et al
Programs
OPN-51107
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