Targeting key regulators of
cancer with unique drug design
for better, safer treatments

OUR PIPELINE

Opna Bio is targeting key regulators to advance the treatment of cancer. OPN-6602, a best-in-class EP300 inhibitor, is currently in clinical development for treatment of patients with multiple myeloma. Zavabresib, a differentiated BET inhibitor, is being developed for the treatment of myelofibrosis.

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Clinical Programs

Opna Bio is dedicated to discovering and developing novel treatments for cancer patients everywhere.

We are currently validating our approach of competitive safety and efficacy through differentiated PK with our epigenetic inhibitors, OPN-6602 and zavabresib. Both compounds are currently in early-stage clinical development in patients with hematologic malignancies.

Explore our Clinical Trials

LATEST NEWS

Opna Bio Announces Orphan Drug Designation Granted to OPN-2853 (Zavabresib) for the Treatment of Myelofibrosis

SOUTH SAN FRANCISCO, CA – January 21, 2026 – Opna Bio, a clinical-stage biopharmaceutical company focused on the discovery and […]

Opna Bio Showcases Multi-Functional Degraders with Potent Anti-Myeloma Activity and Encouraging Spleen Reductions in Patients with Myelofibrosis Treated with OPN-2853 and Ruxolitinib

Data were shared at the 67th Annual Meeting of the American Society of Hematology (ASH)

Opna Bio Announces 2025 ASH Presentations Highlighting Preclinical Data from Novel Protein Degrader Program and Updated Interim Data from Phase 1 Combination Study of OPN-2853 with Ruxolitinib in Advanced Myelofibrosis

Phase 1 Clinical Trial with OPN-6602 in Multiple Myeloma Actively Enrolling Patients